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Author summary Proteins fold into three-dimensional structures that are essential for their function. Because these structures depend on interactions among amin...
Author summary The DNA sequence surrounding a nucleotide strongly influences how likely it is to mutate. An extreme example is the CpG dinucleotide: cytosines i...
Secondary palate formation is a complex process that is frequently disturbed in mammals, resulting in the birth defect cleft palate1,2. Gene targeting has ident...
Peroxisomes are essential organelles in almost all eukaryotic cells with a variety of functions in cellular metabolism, including β-oxidation of very-
This study uncovered the genetic basis of leaf variegation for 35 diverse flowering plants. The underlying loss-of-function plastome mutations in albino se
Our genes make us who we are—but are they products of chance, natural selection, or something else?
Archaic DNA that once helped us fight RNA viruses appears to leave carriers more vulnerable to a different class of persistent pathogens — and the genome is s...
Extreme values for cholesterol, glucose, and height are driven by rare, high-impact genetic variants rather than polygenic traits.
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